目前似乎还没有_明确的直接证据，但有几个角度可能值得探讨：
分子动力学（MD）模拟发现姜黄素是一种稳定的芳香化酶抑制剂（Singh et al 2016）。
芳香化酶抑制剂可作为治疗乳腺癌、子宫内膜异位症、子宫内膜异位症、利肌瘤（纤维瘤）、特发性矮小身材、妇科腺瘤和男性性腺功能减退症的治疗药物，因为它们可以防止雌激素的形成（Le Ray等人2012；Pavone和Bulun 2012；Singh 2013；Hero 2016；Blakemore和Naftolin 2016；Miller等人2016）。
Singh S, Awasthi M, Pandey VP, Dwivedi UN (2016) Plant derived anti-cancerous secondary metabolites as multipronged inhibitor of COX, Topo and aromatase: Molecular modeling and dynamics simulation analyses. J Biomol Struct Dyn 1-65. doi: 10.1080/07391102.2016.1241720
Metwalley KA, Farghaly HS (2013) Aromatase excess syndrome presenting with prepubertal gynecomastia in an Egyptian child with type 1 neurofibromatosis. Indian J Hum Genet 19:472-4. doi: 10.4103/0971-6866.124379
Singh SK (2013) Aromatase inhibitors in male sex. Indian J Endocrinol Metab 17:S259-61. doi: 10.4103/2230-8210.119594
Blakemore J, Naftolin F (2016) Aromatase: Contributions to Physiology and Disease in Women and Men. Physiology (Bethesda) 31:258-69. doi: 10.1152/physiol.00054.2015
Seema Patel: “Disruption of aromatase homeostasis as the cause of a multiplicity of ailments: A comprehensive review”,The Journal of Steroid Biochemistry and Molecular Biology, Volume 168, April 2017, Pages 19-25 (DOI http://dx.doi.org/doi:10.1016/j.jsbmb.2017.01.009 https://www.sciencedirect.com/science/article/abs/pii/S0960076017300092 )
这是相当有希望的，但目前还没有更多的研究。另外，鉴于此一诊断的原因可能https://www.mayoclinic.org/diseases-conditions/gynecomastia/symptoms-causes/syc-20351793 )的众多https://my.clevelandclinic.org/health/diseases/16227-enlarged-male-breast-tissue-gynecomastia )原因。